{"id":9004111222137731,"date":"2020-06-29T14:20:00","date_gmt":"2020-06-29T13:20:00","guid":{"rendered":"https:\/\/www.hgf.com\/?p=9004111222137731"},"modified":"2026-03-26T12:40:45","modified_gmt":"2026-03-26T12:40:45","slug":"la-cour-supreme-du-royaume-uni-invalide-les-brevets-de-souris-transgeniques-de-regeneron-pour-insuffisance-de-description","status":"publish","type":"post","link":"https:\/\/www.hgf.com\/fr\/centre-de-connaissances\/actualites-juridiques\/la-cour-supreme-du-royaume-uni-invalide-les-brevets-de-souris-transgeniques-de-regeneron-pour-insuffisance-de-description\/","title":{"rendered":"La Cour supr\u00eame du Royaume-Uni invalide les brevets de souris transg\u00e9niques de Regeneron pour insuffisance de description"},"content":{"rendered":"

Dans son jugement tr\u00e8s attendu sur le litige concernant les brevets de souris transg\u00e9niques, la Cour supr\u00eame du Royaume-Uni a statu\u00e9 \u00e0 la majorit\u00e9 (Lady Black \u00e9tant dissidente) que les brevets de Regeneron sont invalides pour insuffisance de description (Regeneron Pharmaceuticals Inc (Intim\u00e9e) c. Kymab Ltd (Appelante)<\/em> [2020] UKSC 27)<\/a>.<\/p>\n

Le jugement renforce la jurisprudence \u00e9tablie sur l’insuffisance de description \u2013 \u00e0 savoir qu’une description de brevet doit permettre \u00e0 l’homme du m\u00e9tier de r\u00e9aliser substantiellement toute la gamme des produits relevant d’une revendication \u00e0 la date de priorit\u00e9. La Cour supr\u00eame a infirm\u00e9 la d\u00e9cision ant\u00e9rieure de la Cour d’appel selon laquelle cette norme d’insuffisance pourrait \u00eatre assouplie lorsqu’une invention r\u00e9volutionnaire fournit un \u00ab principe d’application g\u00e9n\u00e9rale \u00bb. <\/p>\n

Contexte<\/h5>\n

L’invention de Regeneron concernait des souris transg\u00e9niques qui ont \u00e9t\u00e9 modifi\u00e9es pour produire des anticorps chim\u00e9riques comprenant une r\u00e9gion constante de souris et une r\u00e9gion variable humaine. Kymab a affirm\u00e9 que les brevets de Regeneron (EP1360287 et son divisionnaire EP2264163) \u00e9taient invalides pour insuffisance de description \u2013 l’exigence l\u00e9gale selon laquelle un brevet doit fournir suffisamment d’informations pour permettre \u00e0 l’homme du m\u00e9tier de r\u00e9aliser l’invention. <\/p>\n

La revendication principale sur laquelle reposait la question de l’insuffisance d\u00e9finissait une souris transg\u00e9nique comprenant le remplacement in situ de r\u00e9gions du locus g\u00e9n\u00e9tique d’anticorps de souris par des r\u00e9gions humaines correspondantes (un \u00ab Locus Chim\u00e9rique Inverse \u00bb). Cette revendication a \u00e9t\u00e9 interpr\u00e9t\u00e9e par la Cour d’appel comme couvrant une gamme de produits comprenant certains ou tous les segments de la r\u00e9gion variable humaine. Kymab a fait valoir qu’\u00e0 la date de priorit\u00e9 (f\u00e9vrier 2001), il n’\u00e9tait pas possible d’ins\u00e9rer l’ADN codant pour l’ensemble de la r\u00e9gion variable humaine dans le chromosome de souris, et donc certains produits relevant de la gamme revendiqu\u00e9e ne pouvaient pas \u00eatre r\u00e9alis\u00e9s. <\/p>\n

Points de vue divergents des tribunaux<\/h5>\n

La Cour d’appel a estim\u00e9 que bien que la divulgation du brevet, associ\u00e9e aux connaissances g\u00e9n\u00e9rales communes \u00e0 la date de priorit\u00e9, ne permettait pas de r\u00e9aliser tous les produits relevant de la revendication de Regeneron, l’exigence d’insuffisance \u00e9tait n\u00e9anmoins satisfaite car \u00ab compte tenu de la nature et de l’\u00e9tendue de la contribution que la divulgation de l’invention a apport\u00e9e \u00e0 l’\u00e9tat de la technique, la port\u00e9e de la revendication n’est pas plus que n\u00e9cessaire pour conf\u00e9rer une protection \u00e9quitable<\/em> \u00bb.<\/p>\n

Cependant, apr\u00e8s examen de la jurisprudence britannique et de l’OEB, la Cour supr\u00eame a conclu que la possibilit\u00e9 de r\u00e9alisation sur toute l’\u00e9tendue d’une revendication de produit ne sera pas \u00e9tablie simplement en d\u00e9montrant que tous les produits de la gamme concern\u00e9e fourniront (s’ils peuvent \u00eatre r\u00e9alis\u00e9s \u00e0 l’avenir) le b\u00e9n\u00e9fice de l’invention, quelle que soit l’importance r\u00e9volutionnaire de l’invention.<\/p>\n

Le jugement de la Cour supr\u00eame reposait sur le concept du \u00ab contrat de brevet \u00bb. En contrepartie d’un monopole sur un produit ou un proc\u00e9d\u00e9 revendiqu\u00e9, le titulaire du brevet doit fournir suffisamment d’informations pour que d’autres puissent utiliser l’invention apr\u00e8s l’expiration du brevet. La Cour supr\u00eame a estim\u00e9 que l’exigence d’insuffisance n’\u00e9tait satisfaite que si la divulgation du brevet, associ\u00e9e aux connaissances g\u00e9n\u00e9rales communes \u00e0 la date de priorit\u00e9, permettait \u00e0 l’homme du m\u00e9tier de r\u00e9aliser substantiellement tous les types de produits relevant de la gamme revendiqu\u00e9e. \u00c9tant donn\u00e9 que les souris contenant une grande partie ou la totalit\u00e9 du locus de la r\u00e9gion variable humaine, qui sont plus pr\u00e9cieuses, ne pouvaient pas \u00eatre r\u00e9alis\u00e9es en utilisant les enseignements du brevet, le monopole revendiqu\u00e9 par Regeneron a \u00e9t\u00e9 jug\u00e9 comme s’\u00e9tendant au-del\u00e0 de la contribution apport\u00e9e par le titulaire du brevet \u00e0 l’\u00e9tat de la technique. <\/p>\n

Conclusions<\/h5>\n

Le jugement majoritaire de la Cour supr\u00eame a \u00e9t\u00e9 sans \u00e9quivoque dans son soutien au droit \u00e9tabli sur l’insuffisance, allant jusqu’\u00e0 dire que la Cour d’appel avait \u00ab dilu\u00e9 l’exigence d’insuffisance qui est un fondement du droit des brevets, faisant pencher la balance du droit des brevets en faveur des titulaires de brevets et au d\u00e9triment du public<\/em> \u00bb.<\/p>\n

Le jugement sert de rappel aux titulaires de brevets sur l’importance fondamentale de satisfaire au \u00ab contrat de brevet \u00bb. Les revendications excessives qui ne peuvent \u00eatre correctement justifi\u00e9es par la contribution technique apport\u00e9e \u00e0 l’\u00e9tat de la technique sont invalides. Il est donc rappel\u00e9 aux demandeurs de r\u00e9sister \u00e0 la tentation d’\u00e9tendre leurs revendications au-del\u00e0 des limites de ce qu’ils ont r\u00e9alis\u00e9 et test\u00e9 sans justification raisonnable. <\/p>\n

Cet article a \u00e9t\u00e9 pr\u00e9par\u00e9 par Rachel Fetches<\/a>, Associ\u00e9e chez HGF, et Dr Jennifer Bailey<\/a>, Directrice des brevets. Si vous souhaitez obtenir des conseils suppl\u00e9mentaires sur ce sujet ou sur toute autre question, veuillez contacter Rachel ou Jennifer. Vous pouvez \u00e9galement contacter votre repr\u00e9sentant HGF habituel ou consulter notre page Contact<\/a> pour joindre le bureau HGF le plus proche. <\/p>\n","protected":false},"excerpt":{"rendered":"

Dans son jugement tr\u00e8s attendu sur le litige concernant les brevets de souris transg\u00e9niques, la Cour supr\u00eame du Royaume-Uni a statu\u00e9 \u00e0 la majorit\u00e9 (Lady Black \u00e9tant dissidente) que les …<\/p>\n","protected":false},"author":315,"featured_media":9004111222139205,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[548,517],"tags":[],"class_list":["post-9004111222137731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-juridiques","category-centre-de-connaissances","sector-produits-pharmaceutiques","service-brevets","sector_groups-droit"],"acf":[],"yoast_head":"\nLa Cour supr\u00eame du Royaume-Uni invalide les brevets de souris transg\u00e9niques de Regeneron pour insuffisance de description - HGF<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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